Long standing cases of IDDM live in the same pathologic environement resulting in obesity and related disorders or the metabolic syndrome. This patients usually develop insulin resistance and progressively need larger doses of insulin which would aggravate weight gain.
The use of insulin sensitizers like metformin and thiazolidinediones may have important roles to ameliorate this situation.
Note that thiazolidinediones have salutary resluts only in black subjects.
It is not yet clear if Avandia really have a tendency for the induction of IHD although a shift to Actos may be wise.
Patient usually do not realize the imporance of a cheap durg like Metformin.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment